Thomas Unger Selected Research

Type 2 Angiotensin Receptor

1/2018	The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.
1/2018	The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role.
1/2018	AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat.
1/2017	The angiotensin type 2 receptor and the kidney.
1/2016	Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders.
1/2016	The angiotensin II type 2 receptor agonist Compound 21 is protective in experimental diabetes-associated atherosclerosis.
5/2015	AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy.
6/2014	The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.
3/2014	Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart.
11/2013	Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure.

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Thomas Unger Research Topics

Disease

42	Hypertension (High Blood Pressure) 12/2020 - 01/2000
16	Cardiovascular Diseases (Cardiovascular Disease) 03/2015 - 01/2002
15	Stroke (Strokes) 01/2016 - 06/2004
14	Inflammation (Inflammations) 02/2016 - 03/2002
14	Infarction (Infarctions) 01/2016 - 10/2002
13	Heart Failure 02/2014 - 01/2002
12	Myocardial Infarction 07/2013 - 10/2002
10	Obesity 12/2021 - 10/2004
10	Fibrosis (Cirrhosis) 01/2018 - 01/2003
10	Insulin Resistance 01/2016 - 05/2004
6	Diabetic Nephropathies (Diabetic Nephropathy) 01/2017 - 03/2003
6	Atherosclerosis 02/2016 - 05/2003
6	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2016 - 03/2008
6	Type 2 Diabetes Mellitus (MODY) 12/2014 - 05/2004
6	Brain Ischemia (Cerebral Ischemia) 06/2014 - 04/2005
5	Vascular Remodeling 12/2021 - 03/2002
5	Body Weight (Weight, Body) 06/2008 - 06/2004
4	Cognitive Dysfunction 10/2018 - 01/2011
4	Aneurysm (Aneurysms) 01/2018 - 09/2004
4	Albuminuria 01/2016 - 12/2005
4	Ischemia 11/2010 - 10/2002
3	Abdominal Aortic Aneurysm 01/2018 - 12/2008
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2013 - 04/2007
3	Weight Gain 07/2013 - 12/2005
3	Neoplasms (Cancer) 12/2012 - 12/2011
3	Cardiomegaly (Heart Hypertrophy) 07/2004 - 01/2002
2	Lung Injury 01/2018 - 01/2004
2	Diabetes Mellitus 05/2015 - 06/2013
2	Leukemia 01/2013 - 01/2011
2	Cardiomyopathies (Cardiomyopathy) 10/2012 - 05/2006
2	Heart Diseases (Heart Disease) 10/2012 - 07/2004
2	Glucose Intolerance 10/2010 - 06/2008
2	Disease Progression 10/2010 - 01/2008
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 09/2010 - 12/2003
2	Coronary Artery Disease (Coronary Atherosclerosis) 09/2010 - 07/2008
2	Necrosis 12/2008 - 03/2005
2	Metabolic Diseases (Metabolic Disease) 06/2008 - 12/2005
2	Brain Injuries (Brain Injury) 05/2008 - 04/2005

Drug/Important Bio-Agent (IBA)

22	compound 21IBA 12/2021 - 12/2008
19	Angiotensin IIIBA 01/2020 - 01/2000
19	Telmisartan (Micardis)FDA Link 01/2017 - 05/2003
17	Type 2 Angiotensin ReceptorIBA 01/2018 - 04/2005
13	Antihypertensive Agents (Antihypertensives)IBA 12/2020 - 12/2003
13	AngiotensinsIBA 02/2016 - 07/2004
12	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021 - 01/2004
12	Type 1 Angiotensin ReceptorIBA 01/2016 - 05/2004
11	Ramipril (Altace)FDA LinkGeneric 03/2015 - 03/2003
9	CollagenIBA 01/2018 - 10/2002
9	Proteins (Proteins, Gene)FDA Link 05/2015 - 10/2002
8	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 08/2010 - 01/2002
7	Glucose (Dextrose)FDA LinkGeneric 12/2014 - 05/2004
6	Angiotensin Receptor AntagonistsIBA 01/2021 - 01/2003
6	Pharmaceutical PreparationsIBA 12/2020 - 04/2007
6	Interleukin-6 (Interleukin 6)IBA 12/2011 - 03/2005
6	PPAR gammaIBA 10/2010 - 05/2004
5	Peptides (Polypeptides)IBA 01/2016 - 09/2004
5	ReninIBA 01/2013 - 01/2002
5	candesartanIBA 11/2010 - 11/2003
5	Insulin (Novolin)FDA Link 10/2010 - 03/2003
4	SaltsIBA 01/2017 - 12/2005
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2016 - 03/2005
4	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 06/2013 - 04/2007
4	LigandsIBA 02/2012 - 08/2007
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2011 - 03/2005
4	Neuroprotective AgentsIBA 03/2011 - 04/2005
4	Messenger RNA (mRNA)IBA 01/2011 - 10/2002
4	Irbesartan FDA LinkGeneric 04/2007 - 04/2005
3	icatibantIBA 01/2021 - 01/2003
3	AldosteroneIBA 01/2018 - 03/2008
3	Losartan (Cozaar)FDA LinkGeneric 11/2014 - 02/2005
3	Transcription Factors (Transcription Factor)IBA 01/2013 - 07/2009
3	Prorenin ReceptorIBA 01/2013 - 12/2011
3	olmesartanIBA 02/2012 - 01/2004
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2018 - 01/2004
2	Pancreatic Elastase (Elastase)IBA 01/2018 - 12/2008
2	salicylhydroxamic acid (SHAM)IBA 01/2018 - 12/2008
2	Cytochrome P-450 CYP11B2 (CYP11B2)IBA 01/2018 - 11/2011
2	DiureticsIBA 01/2017 - 01/2013
2	trkB ReceptorIBA 01/2016 - 01/2011
2	AdiponectinIBA 01/2016 - 07/2005
2	Blood Glucose (Blood Sugar)IBA 11/2014 - 04/2007
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 06/2014 - 04/2010
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2014 - 02/2012
2	Olmesartan Medoxomil (Votum)FDA Link 02/2012 - 01/2004
2	CytokinesIBA 12/2011 - 03/2007
2	Endothelin Receptor AntagonistsIBA 11/2011 - 03/2011
2	Neprilysin (Neutral Endopeptidase)IBA 03/2011 - 08/2010
2	aliskiren FDA Link 11/2010 - 02/2010
2	LipidsIBA 09/2010 - 09/2004
2	Valsartan (Vals)FDA Link 09/2010 - 07/2008
2	Renin InhibitorsIBA 02/2010 - 09/2004
2	Matrix Metalloproteinases (MMPs)IBA 01/2010 - 03/2007
2	Kininogens (Kininogen)IBA 01/2010 - 09/2004
2	Caspase 3 (Caspase-3)IBA 12/2008 - 12/2008
2	Fas Ligand Protein (Fas Ligand)IBA 12/2008 - 12/2008
2	Nerve Growth Factors (Neurotrophins)IBA 12/2008 - 03/2008
2	Captopril (Capoten)FDA LinkGeneric 07/2008 - 12/2005

Therapy/Procedure

13	Therapeutics 01/2021 - 01/2004
3	Ligation 12/2008 - 10/2002
2	Denervation 03/2012 - 08/2010